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Pathology
A super-antigen is a bacterial product that
Binds to B7 and CD28 co-stimulatory molecules
Binds to the beta chain of TCR and MHC class II molecules of APC stimulating T cell activation
Binds to the CD4 + molecule causing T cell activation
Is presented by macrophages to a larger-than-normal number of T helper CD4 + lymphocytes
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