Redness (due to vasodilatation of small blood vessels) ii) Tumor Swelling (due to exudation of fluid) iii) Color --> Heat (due to increased blood flow i.e., hypermia which is caused by vasodilatation). iv) Dolor --> Pain (Due to stretching of tissue from edema and also from chemical mediators, bradykinin) A fifth clinical sign was added later by Virchow v) Functio laesa --> Loss of function 2. Chronic inflammation Slow in onset Of longer duration Characterized by presence of lymphocytes & macrophages the proliferation of blood vessels, fibrosis and tissue necrosis. Signs of acute inflammation (i.e., Cardinal signs of inflammation) are not present.">