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Pathology
All of the following statement are true regarding silicosis, except:
Crystalline forms are much more fibrogenic
Phagocytosed silica crystals activate the inflammasome, leading to the release of inflammatory mediators, paicularly IL-2 and TNF
As the disease progresses, nodules coalesce into hard, collagenous scars
Histologic examination reveals the hallmark lesion characterized by a central area of whorled collagen fibers with a more peripheral zone of dust-laden macrophages.
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