(Ref: )Most cases of Hirschsprung disease are diagnosed in the newborn period. Hirschsprung disease should be considered in any newborn that fails to pass meconium within 24-48 hours of birth-option b trueDistal intestinal segment that lacks both the Meissner submucosal and the Auerbach myenteric plexus. - option a is trueProximal to aganglionic segment, colon undergoes progressive dilationRectal examination may demonstrate a tight anal sphincter and explosive discharge of stool and gas - option d is falseA rectal suction biopsy can detect hypertrophic nerve trunks and the absence of ganglion cells in the colonic submucosa, confirming the diagnosis.- option c is trueDown syndrome (trisomy 21) is the most common chromosomal abnormality associated with the disease, accounting for approximately 10 percent of patients">