best screening test. o But, not specific because patients with other autoimmune diseases also show positive test. 2. Anti ds DNA antibody o Most specific for SLE o Not sensitive 3. Anti Smith (Sm) antibody o Along with anti ds DNA antibody, most specific for SLE. o Not sensitive 4. Antihistone antibody Paicularly seen in drug induced SLE. 5. Anti RNP- SS - A (Ro), SS-B (La) Seen in neonatal lupus with congenital hea block and in subacute cutaneous lupus. o Associated with decreased risk of lupus nephritis. o More common in sjogren syndrome (Sicca syndrome). 6. Anti Ui RNP Seen in patients that have overlap feature of several rheumatic syndromes including SLE Mixed connective tissue disease. 7. Anti DNA topoisonerase (Scl - 70) o In less than 5% of patients of SLE. o More common in patients with systemic sclerosis. 8. Anticentromere In less than 5% of patients of SLE. More common in patiens with localized form of systemic sclerosis, i.e. scleroderma. 9. Anti-histidyl t-RNA systhatase In less than 5% of SLE patiens. o More common in patiens with inflammatory myopathies. Besides antinuclear antibodies following antibodies are also seen in SLE ? 1. Antiphospholipid (lupus anticoagulant) 2. Antierythrocyte ---> causes hemolytic anemia 3. Antiplatelet --> Causes thrombocytopenia 4. Antiribosomal P 5. Antineuronal">