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Pathology
A 50-year-old man Shahid K. John has had increasing dyspnea for the past 3 years with associated occasional cough but little sputum production. Auscultation reveals that his lungs are hyper-resonant and is associated with expiratory wheeze. Pulmonary function tests reveal increased total lung capacity (TLC) and slightly increased FVC. There is decreased FEV1 and FEV1/FVC ratio also. ABG analysis reveals pH of 7.35, pO2 of 60 mm Hg and pCO2 of 48 mm Hg. What is the most likely diagnosis?
Centriacinar emphysema
Sarcoidosis
Diffuse alveolar damage
Chronic pulmonary embolism
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