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Pathology
A 40-year-old man is pulled from the ocean after a boating accident and resuscitated. Six hours later, the patient develops acute renal failure. Kidney biopsy reveals evidence of karyorrhexis and karyolysis in renal tubular epithelial cells. Which of the following biochemical events preceded these pathologic changes?
Activation of Na+/K+ ATPase
Decrease in intracellular calcium
Decrease in intracellular pH
Increase in ATP production
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