Cupping is associated with the loss of ganglion cell axons.# Angle-closure glaucoma:> is characterized by narrowing or closure of the anterior chamber angle.> Normal anterior chamber angle provides drainage for the aqueous humor (the fluid that fills the eyeball).> When this drainage pathway is narrowed or closed, inadequate drainage leads to elevated intraocular pressure and damage to the optic nerve.> Acute angle-closure glaucoma occurs in eyes with a certain anatomical predisposition.> It presents as a painful red eye and must be treated within 24 hours to prevent permanent blindness.">