2-15 days (5 days) A headache, high fever, nausea, vomiting, meningismus. Cranial nerve palsies -->> 3rd.4* and 6th Most patients die within a week (95%). N. fowleri also causes humidifier fever a form of allergic alveolitis resulting from inhaling air from air -coolers, o Diagnosis Detection of motile amoeboid trophozoites in wet mounts of C.S.F. o Treatment High doses of amphotericin B and rifampicin. Acanthamoeba o It is a free-living amoeba o Acanthamoeba culbertsoni species is most common, o Exists in two stages Trophozoite Cyst o The flagellate stage is absent o Modes of transmission Through contamination of traumatized skin or eye Inhalation o C.'Fs Granulomatous amoebic encephalitis (GAE) Keratitis (in contact lens users) o Diagnosis Examination of CSF for trophozoites Corneal scraping for cysts, o Treatment No satisfactory treatment is available for GAE For keratitis - Neomycin, Propenamide">