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Microbiology
During an infection with Streptococcus pyogenes, an individual generated sufficiently high levels of IgM and IgG antibodies against Streptococcus pyogenes antigen with structural similarities to the heart that cardiac damage was caused. In this example the microbe contributed to autoimmunity via a process known as:
Anergy
Central tolerance
Epitope spreading
Molecular mimicry
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