3", 41th and 6th - Most patients die within a week (95%). - N. foweleri also causes humidifier fever a form of allergic alveolitis resulting from inhaling air from air -coolers. . Diagnosis - Detection of motile amoeboid trophozoites in wet mounts of C.S.F. . Treatment - High doses of amphotericin B and rifampicin. Acanthamoeba . It is a free living amaeba . Acanthamoeba culbesoni species is most common. . Exists in two stages a) Trophozoite b) Cyst . Flagellate stage is absent . Modes of transmission - Through contamination of traumatized skin or eye - Inhalation . C/Fs a) Granulomatous amoebic encephalitis (GAE) b) Keratitis (in contact lens users) . Diagnosis - Examination of CSF for trophozoites - Corneal scraping for cysts. . Treatment - No satisfactory treatment is available for GAE - For keratitis --> Neomycin, Propamide and dibromopropamide">