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Microbiology
A 1-week-old neonate presents to the pediatric emergency room with fever, irritability, poor feeding, and a bulging anterior fontanelle. Lumbar puncture is performed, and the cerebrospinal fluid (CSF) grows group B Streptococcus. Which of the following is the most likely pathogenic mechanism?
Complement C5a, a potent chemoattractant, activates polymorphonuclear neutrophils (PMNs)
In the absence of a specific antibody, opsonization, phagocyte recognition, and killing do not proceed normally
The alternative complement pathway is activated
The streptococci are resistant to penicillin
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