Medicine

A 56-year-old man complains of increased thirst and increased urinary volume and frequency. He has also noticed new symptoms of constipation and generalized aches and pains. He has no significant past medical problems and his physical examination is normal. Initial investigations consist of a normal complete blood count (CBC) fasting blood glucose and urinalysis. His sodium, urea, and creatinine are normal, but calcium is 12.4 mg/dL (8.4-10.2 mg/dL). Further testing reveals an elevated PTH level. Which of the following is the most likely mechanism for the polyuria in this condition?