5 L in adults) I unit =150-250 ml About 1 h to thaw (400 - if ml (400-600 - single-donor single * Hypoglobulinemia (IV immune globulin preferred) pheresis) * Suspected or documented coagulopathy (congenital or acquired) with active bleeding or before surgery * Clotting factor replacement when concentrates unavailable * Not recommended for volume replacement">