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All are TRUE about Antineutrophil Cytoplasmic Antibodies, EXCEPT:
Proteinase-3, in neutrophil azurophilic granules, is the major cANCA antigen
The major target for pANCA is the enzyme myeloperoxidase
A pANCA pattern of staining has been associated with nonvasculitic entities such as rheumatic and nonrheumatic autoimmune diseases
There are three major categories of ANCA
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