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Medicine
A 63 year old man presented with back pain since few weeks. Blood investigation shows anemia, hypercalcemia and hypoalbuminemia. Serum protein electrophoresis (PEP) demonstrates an M spike. All of the following are MINOR criteria for diagnosis of multiple myeloma, EXCEPT:
Bone marrow plasmacytosis = 20%
Multiple lytic lesions on skull X-ray
Plasmacytoma on tissue biopsy
Monoclonal spike < 3.5g/dL for IgG and < 2g/dL for IgA
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