0.5g/ day to end stage renal disease; such as:- Cellular casts, Glomerulonephritis, azotemia, pyuria, uremia, HTNCerebralSeizures, psychosis (may be subtle), meningitis TIA, cerebrovascular accidentSerology* ANA. It is 95 % sensitive but not specific; almost all patients with SLE have elevated serum ANA levels.* Anti-ds DNA (60-70%) or anti-Sm (Smith) (10-20%). The presence of either of these is diagnostic of SLE--very specific (but obviously not sensitive)NoteEach of the serologic abnormalities counts as 1 criterion. Hence, if the person has joint pain, a rash, and both an ANA and DS DNA, that patient would have 4 criteria.Points to RememberDiagnostic Test for SLE* Best initial test: ANA* Most specific test: Anti-DS DNA (60-70%) or anti-Sm (Smith) (10-20%)..* Rule of thumb- ANA positivity is a must in SLE diagnosis.* ANA negativity twice rules out SLE. Even though ANA positivity cannot confirm SLE - negativity can rule out.Note* There is no ANA negative SLE. But there is ANA negative scleroderma* Also Drug induced lupus - secondary to Quinidine/ Minocycline tends to be ANA negative.">