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A 70 year old male patient dies with severe dementia. Autopsy demonstrates marked atrophy of the frontal and temporal lobes, with relative sparing of the rest of the brain. Which of the following microscopic features would be most useful in establishing the diagnosis?
Enlarged presynaptic axon terminals surrounding a central core of extracellular amyloid-like substance
Intracytoplasmic spherules composed of paired helical filaments
Intracytoplasmic spherules that stain brightly eosinophilic
Intranuclear and intracytoplasmic inclusion bodies in enlarged cells
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