The CSF is acellular with a normal or mildly elevated protein level and a markedly elevated globulin level (>20% of total CSF protein). CSF antimeasles antibody levels are invariably elevated, and oligoclonal antimeasles antibodies are often present.> CT and MRI show evidence of multifocal white matter lesions and generalized atrophy. Measles virus can be cultured from Drain tissue, and viral genome can be detected by in situ hybridization or PCR amplification.> Treatment with isoprinosine (Inosiplex) (100 mg/kg per day), alone or in combination with intrathecal or intraventricular interferon has been reported to prolong survival and produce clinical improvement in some patients but has never been subjected to a controlled clinical trial.">