95%), but they are not specific for scleroderma0. Scleroderma is associated with wide array of autoantibodies. Two ANA'S which are more or less unique to scleroderma are: Antitopoisomerase antibody (20-40%) Seen in patients with diffuse systemic sclerosis Patients with this autoantibody are more likely to havepulmonary .fibrosis and peripheral vascular disease Patients with these autoantibodies have poor prognosis Anticentromere antibody (20-40%) These autoantibodies are seen in patients with limited systemic sclerosis">