one effect on an individual's phenotype5.ImprintingDifferences in phenotype depend on whether the mutation is of maternal or paternal origin (e.g., Angelman's syndrome , Prader-Willi syndrome )6.AnticipationSeverity of disease worsens as age of onset of disease is earlier in succeeding generation (e.g., Huntington's disease)7.Loss of heterozygosityIf patient inherits or develops mutation in a tumor suppressor gene, complementary allele must be deleted/mutated before cancer develops. This is not true of oncogenes.8.Dominant negative mutationExerts a dominant effect. A heterozygote produces a nonfunctional altered protein that prevents the normal gene product from functioning.9.Linkage disequilibriumTendency for certain alleles at 2 linked loci to occur together often than expected by chance. Measured in a population, not in family; and often varies in different populations.10.MosaicismOccurs when cells have different genetic makeup (e.g.Lyonization-random X-inactivation in females)">