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Medicine
In the treatment of megaloblastic anemia, vitamin B12 and folic acid should be given together because
Vitamin B12 acts as a cofactor for digydrofolate reductase
Folic acid alone causes improvement of anemic symptoms but neurological dysfunction continues
Vitamin B12 deficiency may result in methylfolate trap
Folic acid is required for conversion of methymalonyl-CoA to succinyl Co-A
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