80 years.o Preexisting renal problems Great >2 mg/ dL.o DM.o Dehydration.o Solitary kidneyo Paraproteinemia.o Nephrotoxic drug usageo High contrast dose.Adequate prior HYDRATION may prevent this condition.Nonionic, low osmolar contrast media cause less renal cell damage.Sodium bicarbonate or N-acetylcysteine may decrease this.When eGFR < 45 mi/min/1.73m2 - iodinated contrast must be avoided.Risk of Anaphylaxiso With iodinated contrast 0.24%o With nonionic media- 0.04%.Premedication in high risk patientso Glucocorticoids.o H2 blockers (ranitidine)o H1 blockerantihistaminics.High risk patients - Anaphylaxiso Prior contrast allergy.o Food allergy to shellfisho Atopy (asthma or hay fever).NOTEMR contrast with gadolinium is less risky.But, when eGFR">