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Biochemistry
A decrease in the level of heme leads to a reduction in globin synthesis in reticulocytes. Which of the following best explains this phenomenon?
RNA polymerase activity is decreased in reticulocytes by low heme
The initiation factor eIF-2 becomes phosphorylated,reducing its level of activity
Heme normally activates peptidyl transferase in reticulocytes
A tRNA degrading enzyme is active in the absence of heme
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