Typical cells (called Niemann-Pick cells)that have a foamy appearance due to their storage of sphingomyelin are found in the bone marrow, spleen and lymph nodes.> Neurological features of Niemann-Pick disease include mental retardation, spasticity, seizures, jerks, eye paralysis (ophthalmoplegia) and ataxia (wobbliness). Physical growth is retarded.> Gastrointestinal features include hepatosplenomegaly, jaundice, hepatic (liver) failure, and ascites (fluid in the abdomen).> Eye hallmarks of Niemann-Pick disease include the "cherry red spot" in the macula in the center of the retina, opacity of the cornea and brown discoloration of the lens capsule. Respiratory problems include pulmonary infiltration.> Coronary artery disease occurs early. There is easy bruising.">