Drug with high plasma protein binding have
Correct Answer: Lower volume of distribution
Description: Ref-KDT 6/e p22 Plasma protein binding causes restriction of drugs in the vascular compament and thus lower volume of distribution. Longer duration of action - as the protein-bound fraction is not available for metabolism ofexcretion. Plasma protein bound drugs tend to have more drug internactions due to displacement of a drug with lower affnity by a drug ywith higher affinity for plasma proteins. Hypoalbuminemia can lead to high concentration of free drug and thus drug toxity.
Category:
Anatomy
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now