All of the following factors tend to increase the volume of distribution of a drug EXCEPT:
Correct Answer: High plasma protein binding
Description: - Factors affecting drug distribution
Lipid solubility - Higher the solubility, higher the distribution
Ionization at physiological pH - Higher the ionization, lower the distribution
Degree of plasma protein binding - More the binding, less the distribution
Affinity for different tissues - Higher affinity, higher distribution
Regional blood flow - More the flow, more the distribution
Fat: lean body mass ratio (changes with age) - Increases with age
Disease like CHF, uremia, cirrhosis
Category:
Pharmacology
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