Which one of the following is the most significant risk factor for the development of gastric carcinoma?
Correct Answer: Intestinal metaplasia
Description: " The risk of tumor development is greatly increased in patients in whom mucosal inflammation progresses to multifocal mucosal atrophy and intestinal metaplasia"- Robbins
"Serial endoscopic examinations of the stomach in patients with atrophic gastritis have documented replacement of the usual gastric mucosa by intestinal-type cells. This process of intestinal metaplasia may lead to cellular atypia and eventual neoplasia" - Harrison
Category:
Pathology
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