All Subjects Medicine Surgery Pathology Anatomy Pharmacology Social & Preventive Medicine Microbiology Gynaecology & Obstetrics Dental Physiology Biochemistry Pediatrics
Showing 188245 questions
Sort:
4331 Pathology

A 22-year-old man has a sudden loss of vision in the right eye. On physical examination, there is a subluxation of the right crystalline lens. On auscultation of the chest, a midsystolic click is audible. An echocardiogram shows a floppy mitral valve and dilated aortic arch. The patient’s brother and his cousin are similarly affected. He is prescribed a beta-blocker. A genetic defect involving which of the following substances is most likely to be present in this patient?

ACollagen
BDystrophin
CFibrillin-1
DNF1 protein
Pathology
View Explanation →
4338 Medicine

A 53 year old male presents with an enlarged supraclavicular lymph node, and examination reveals enlargement of the Waldeyer ring of oropharyngeal lymphoid tissue. There is no hepatosplenornegaly. Lymph node biopsy reveals replacements by a monomorphous population of large lymphoid cells with enlarged nuclei and prominent nucleoli. The CBC is normal except for finding of mild anemia. Immunohistochemical staining and flow cytometry of the node reveals that most lymphoid cells are CDl9 CD10=,CD3-, CD15-, and negative (TdT). These findings are most consistent with a diagnosis of

AChronic lymphadenitis
BDiffuse large B-cell lymphoma
CHodgkin disease
DLymphoblastic lymphoma
Medicine
View Explanation →