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188104 Pathology

A 45-year-old woman complains of severe headaches and difficulty in swallowing. Over the past 6 months, she has noticed small, red lesions around her mouth as well as thickening of her skin. The patient has “stone facies” on physical examination. Which of the following antigens is the most common and most specific target of autoantibody in patients with this disease?

AC-ANCA (anti-proteinase-3)
BDouble-stranded DNA
CP-ANCA (anti-myeloperoxidase)
DScl-70 (anti-topoisomerase I)
Pathology
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