Zero-order kinetics occur in the following drug with high dose
Correct Answer: Phenytoin and Theophylline
Description: zero order kinetics -the rate of elimination remains constant irrespective of drug concentration, clearance decreases with increase in concentration, or a constant amount of drug is eliminated in unit time The elimination of some drugs changes from first order to zero order at higher doses eg ; Phenytoin, Tolbutamide, Theophylline, Warfarin, DIGOXIN, aspirin ref; KD Tripathi Pharmacology 7th edition (page no;31 )
Category:
Pharmacology
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