**Core Concept**
The question is testing the student's knowledge of a specific side effect of an alkylating agent, a class of chemotherapy drugs used in cancer treatment. Disulfiram-like reactions are a well-known side effect of certain medications, including some alkylating agents.
**Why the Correct Answer is Right**
The correct answer is likely to be an alkylating agent that inhibits aldehyde dehydrogenase (ALDH), an enzyme involved in the breakdown of acetaldehyde in the liver. When ALDH is inhibited, acetaldehyde builds up and causes a disulfiram-like reaction, characterized by symptoms such as flushing, nausea, and vomiting. The alkylating agent that is known to cause this reaction is cyclophosphamide.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it is not an alkylating agent known to cause disulfiram-like reactions.
* **Option B:** This option is also incorrect because it is not an alkylating agent that inhibits ALDH.
* **Option C:** This option is incorrect because it is a different class of chemotherapy drug that does not cause disulfiram-like reactions.
**Clinical Pearl / High-Yield Fact**
When prescribing alkylating agents, it's essential to be aware of potential side effects, including disulfiram-like reactions. This can be particularly relevant in patients who consume alcohol or have a history of substance abuse.
**Correct Answer:** C. Cyclophosphamide
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
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