With regard to the malignant behaviour of leiomyosarcoma, the most important criterion is –
Correct Answer: The number of mitoses per high power field
Description: The distinction of Leiomyosarcoma from Leiomyomas:
It is based on the combination of:
The degree of nuclear atypia
Mitotic index
Zonal Necrosis
The most important single criteria are the number of nuclear mitosis present
With or without Nuclear atypia (Independent of nuclear atypia) → The presence of ten or more mitoses per ten high power (x400) fields indicates malignancy with or without cellular atypism.
In presence of nuclear atypia or large cells → If the tumor contains nuclear atypia or large epithelioid cells, five mitoses per ten high power fields are sufficient to justify a diagnosis of malignancy.
Category:
Pathology
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