Why is the effect of local anaesthesia slow in infected tissues

A. Less vascularity causing poor diffusion of drug

B. Rich in enzymes that metabolize the drug

C. Low extracellular pH that hinders diffusion of drug into cell

D. Rich in K+ that inhibits binding of the drug to the receptor

Correct Answer: Low extracellular pH that hinders diffusion of drug into cell

Description: In case of infection there is acidic pH of tissue, and in that case local anaesthetics are mostly in ionized form. Ionized form of local anaesthetics is the one that binds to sodium channels, but non-ionized form is the one that is important for membrane penetration. That is the reason for delayed onset of local anaesthetics in site of infection.

Category: Anaesthesia

Share:

← Previous MCQ

Next MCQ →

Get More

Subject Mock Tests

Practice with over 200,000 questions from various medical subjects and improve your knowledge.

Attempt a mock test now

Mock Exam

Take an exam with 100 random questions selected from all subjects to test your knowledge.

Coming Soon

Get More

Subject Mock Tests

Try practicing mock tests with over 200,000 questions from various medical subjects.

Attempt a mock test now

Mock Exam

Attempt an exam of 100 questions randomly chosen from all subjects.

Coming Soon