Physiology Why is the Action Potential of a neuron initiated at the Axon Hillock-Initial segment? A It is an unmyelinated segment B Neurotransmitter is released at this site C It has the lowest threshold for excitation D It has the lowest concentration of voltage gated sodium channels 💡 Explanation Why is the Action Potential of a neuron initiated at the Axon Hillock-Initial segment? ✓ Correct Answer: C. It has the lowest threshold for excitation