Why does decreased glycolytic activity impair oxygen transpo by hemoglobin?
Correct Answer: Due to decreased production of 2,3-bisphosphoglycerate
Description: 2,3-Bisphosphoglycerate (2,3-BPG) is the most abundant organic phosphate in the erythrocytes. It is produced in the erythrocytes from an intermediate (1,3-biphosphoglycerate) of glycolysis. This sho pathway is called Rapapo-Leubering cycle. It normally binds to hemoglobin and decrease it's affinity to oxygen and thereby helps in oxygen delivery. When glycolytic activity is reduced, oxygen transpo by hemoglobin is impaired due to decreased production of 2,3 BPG. In hypoxia and anemia 2,3-BPG in the erythrocytes is elevated. Ref: Essentials of Biochemistry, Satyanarayanan, Page 108
Category:
Biochemistry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now