White infact is seen in –
**Core Concept**
White infarct, also known as white thrombus, is a type of arterial thrombosis characterized by the accumulation of platelets, fibrin, and leukocytes, leading to occlusion of the affected vessel. This process typically occurs in the setting of arterial ischemia, where the blood flow is severely compromised.
**Why the Correct Answer is Right**
The formation of a white infarct is mediated by the activation of platelets, which aggregate and release various chemical signals, including adenosine diphosphate (ADP) and thromboxane A2. These signals attract more platelets, forming a platelet plug that eventually becomes a stable thrombus. The involvement of leukocytes, particularly neutrophils, contributes to the inflammatory response and further exacerbates tissue damage.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because white infarct is not typically associated with venous thrombosis, which is characterized by a red or hemorrhagic infarct.
* **Option B:** This option is incorrect because white infarct is not a type of myocardial infarction; rather, it is a specific histopathological finding that can occur in various organs, including the brain, kidneys, and intestines.
* **Option C:** This option is incorrect because white infarct is not a type of infarct that occurs in the setting of sepsis; while sepsis can cause disseminated intravascular coagulation (DIC), which may lead to microthrombi formation, it is not a characteristic feature of white infarct.
**Clinical Pearl / High-Yield Fact**
White infarct is often associated with a poor prognosis and high mortality rate, particularly if not promptly treated. It is essential for clinicians to recognize the characteristic features of white infarct, such as a sudden onset of symptoms, severe pain, and absence of hemorrhage, to initiate timely and appropriate management.
**Correct Answer: B. White infarct is seen in various organs, including the brain, kidneys, and intestines.**