A 3-year-old child came to OPD with bruising and generalized petechiae. No hepatosplenomegaly or lymphadenopathyis noted. He have ahistory of viral illness 2 weeks back. On investigation a normal hemoglobin, hematocrit, and white blood cell (WBC) count and differential. The platelet count is 19,000/iL. All of the following are associated with above illness except?
A 3-year-old child came to OPD with bruising and generalized petechiae. No hepatosplenomegaly or lymphadenopathyis noted. He have ahistory of viral illness 2 weeks back. On investigation a normal hemoglobin, hematocrit, and white blood cell (WBC) count and differential. The platelet count is 19,000/iL. All of the following are associated with above illness except?
💡 Explanation
**Core Concept**
The underlying condition being tested is likely **Immune Thrombocytopenic Purpura (ITP)**, characterized by isolated thrombocytopenia, which is a decrease in platelet count due to immune-mediated destruction. This condition can be triggered by viral infections.
**Why the Correct Answer is Right**
Given the clinical presentation of bruising, generalized petechiae, and a significantly low platelet count without other cytopenias or organomegaly, the diagnosis points towards ITP. The recent viral illness is a common trigger for ITP, as it can lead to the production of autoantibodies against platelets.
**Why Each Wrong Option is Incorrect**
**Option A:** Would be incorrect if it suggested a condition or factor not typically associated with the development of ITP or thrombocytopenia in this context.
**Option B:** Similarly, if it proposed a mechanism or condition unrelated to immune-mediated platelet destruction.
**Option C:** If it implied a different pathophysiological process or disease entity not consistent with the provided clinical scenario.
**Clinical Pearl / High-Yield Fact**
A key point to remember is that ITP often presents with isolated thrombocytopenia, and a recent viral infection can be a precipitating factor. The absence of hepatosplenomegaly or lymphadenopathy helps differentiate it from other causes of thrombocytopenia.
**Correct Answer:** D.
✓ Correct Answer: D. Cytomegalo virus
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