Which vitamin required for hydroxylation of proline-
Correct Answer: C
Description: Ans. is 'c' i.e., Vitamin C o Hvdroxylation of proline and lysine residue takes place during post-translational modification in rough ER.o The enzyme catalyzing the reactions are prolyl hydroxylase (for proline) and lysvl hydroxylase (for lysine).o Both these enzymes are dioxygenases Q. using molecular oxygen (O2) and cofactor for both these enzymes is vitamin C (ascorbic acid) Q.o a-Ketoglutatrate is a coreductant, which is oxidized to succinate.o These hvdroxylated amino acids are not reprsented in the genetic code (i.e. there is no t-RNA for these Q.), therefore they have to be synthesized post-translationally from proline and lysine residue in the polypeptides.
Category:
Physiology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now