## **Core Concept**
The question pertains to the effects of steroids on different types of blood cells. Steroids, particularly glucocorticoids, have widespread effects on the immune system and hematopoiesis. They can induce changes in the counts of various blood cell types by influencing their production, distribution, and destruction.

## **Why the Correct Answer is Right**
The correct answer, , refers to cells that do not increase in number or are not positively affected by steroid administration. Steroids are known to cause **lymphopenia** (a decrease in lymphocytes) due to their effects on lymphocyte distribution and apoptosis. However, they can cause an increase in **neutrophils** (a type of granulocyte) due to demargination from the vascular endothelium and a decrease in their egress from the circulation. The effect on **eosinophils** and **basophils** can vary, but notably, steroids tend to decrease the number of eosinophils and basophils.

## **Why Each Wrong Option is Incorrect**
- **Option A:** This option would be incorrect because steroids can indeed affect the counts of these cells, typically by decreasing their numbers or altering their function.
- **Option B:** This option might seem plausible but is incorrect because the effect of steroids on certain cell lines does result in changes that could be considered an increase or a significant impact.
- **Option D:** This option is incorrect because it represents a cell type that does have a notable response to steroid administration.

## **Clinical Pearl / High-Yield Fact**
A key point to remember is that glucocorticoids can cause a **redistribution** of lymphocytes, leading to lymphopenia, and can increase neutrophil counts. This effect is utilized in managing conditions like severe asthma or COPD exacerbations. However, the question seems to focus on which cell type does **not** increase, implying a focus on understanding the differential effects of steroids on various leukocytes.

## **Correct Answer: B. Monocytes**