**Core Concept**
Dilated cardiomyopathy (DCM) is a condition characterized by the weakening of the heart muscle, leading to a reduction in the heart's ability to pump blood effectively. This condition is often associated with genetic mutations affecting key proteins involved in cardiac muscle contraction and relaxation.
**Why the Correct Answer is Right**
The protein defective in dilated cardiomyopathy is the beta-myosin heavy chain (MYH7). Mutations in the MYH7 gene can disrupt the normal functioning of the cardiac sarcomere, leading to impaired muscle contraction and relaxation. This results in the characteristic dilated and weakened state of the heart muscle seen in DCM.
**Why Each Wrong Option is Incorrect**
* **Option A:** The protein troponin is involved in the regulation of muscle contraction and is often associated with hypertrophic cardiomyopathy, not dilated cardiomyopathy.
* **Option B:** The protein tropomyosin is also involved in muscle contraction, but it is not directly associated with the pathogenesis of dilated cardiomyopathy.
* **Option D:** The protein desmin is involved in maintaining the structural integrity of cardiac muscle cells, but it is more commonly associated with arrhythmogenic right ventricular cardiomyopathy.
**Clinical Pearl / High-Yield Fact**
Dilated cardiomyopathy is a leading cause of heart failure and can be caused by genetic mutations, viral infections, or other factors. Patients with DCM often present with symptoms of heart failure, including shortness of breath, fatigue, and swelling.
**Correct Answer:** C.
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.