Which poisoning causes ‘Swift Feer disease’?
**Core Concept**
Swift Feer disease, also known as Swainsonine poisoning, is a condition associated with the ingestion of a specific plant compound. This disease results from the accumulation of an abnormal sugar molecule in the body, leading to various systemic effects.
**Why the Correct Answer is Right**
Swainsonine, the causative agent of Swift Feer disease, is a potent inhibitor of glycoprotein processing enzymes. By blocking these enzymes, swainsonine leads to the accumulation of lysosomal glycoproteins in various organs, including the kidneys, liver, and brain. This accumulation causes cellular dysfunction, leading to the characteristic symptoms of Swift Feer disease.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not relate to the specific condition known as Swift Feer disease.
* **Option B:** This option is incorrect because it is associated with a different type of poisoning that affects the nervous system, rather than the metabolic effects seen in Swift Feer disease.
* **Option C:** This option is incorrect because it is a different type of poisoning that affects the cardiovascular system, rather than the metabolic effects seen in Swift Feer disease.
**Clinical Pearl / High-Yield Fact**
Swainsonine poisoning can be treated with alpha-mannosidase inhibitors, which help to restore normal glycoprotein processing and reduce the accumulation of abnormal sugar molecules in the body.
**Correct Answer:** D.