Which one the following does NOT primarily involve an action K+ channels?
Correct Answer: Dantrolene in the treatment of Malignant Hypehermia
Description: Hypoxic pulmonary vasoconstriction and carotid body discharge are brought about by the O2-sensitive K+ channel. Insulin secretion by sulfonylurea is brought about by its action the ATP-sensitive K+ channel on the pancreatic b-cell. Malignant hypehermia is a disorder of excitation-contraction coupling, resulting from genetic defect of RyR (a Ca++-release channel). Dantrolene uncouples the excitation from contraction, by acting on the Ca++ channel.
Category:
Physiology
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