Which one of the following is the earliest manifestation of Cushing’s syndrome :
Correct Answer: Loss of diurnal variation
Description: Nelson writes :
"Laboratoiy .findings (for Cushing Syndrome)"
Cortisol levels in blood are normally elevated at 8 AM and decrease to less than 50% by midnight except in infants and young children in whom a diurnal rhythm is not always established. In patients with cushing syndrome this circadium rhythm is lost, and cortisol levels at midnight and 8 AM are usually comparable. Obtaining diurnal blood samples present logistical difficulties as part of an outpatient evaluation, but cortisol can be measured in saliva samples, which can be obtained at home at the appropriate times of day. Night time salivary cortisol levels are elevated and may be a screening test in obese children.
Category:
Pediatrics
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now