Cupping and fraying of metaphysis of long bones does not occur in lead poisoning. In lead poisoning bone changes become radiologically evident 3 months after chronic lead poisoning. Changes include dense metaphyseal bands exceeding coical density of same bone, found in growing skeleton. Interference with normal modeling may result in splaying of the metaphysis resulting in Erlenmeyer flask deformity. Ref: Bone and Joint Disorders By Francis A. Burgener, Mati Kormano, Tomi Pudas, 2nd Edition, Pages 316, 332; Radiology Review Manual By Wolfgang Dahne, 7th Edition, Page 159; Pediatric Endocrine Disorders By Desai, Meena P, Page 73.