Gynaecology & Obstetrics Which one of the following biochemical parameters is most sensitive to detect open Spina bifida ? A Maternal serum alpha-fetoprotein B Amniotic fluid alpha-fetoprotein C Amniotic fluid acetylcholinesterase D Amniotic fluid glucohexaminase 💡 Explanation Which one of the following biochemical parameters is most sensitive to detect open Spina bifida ? ✓ Correct Answer: C. Amniotic fluid acetylcholinesterase