Which one of the following antipsychotic drugs is considered the best in treatment of Resistant Schizophrenia?
Correct Answer: Clozapine
Description: (B) Clozapine # Clozapine appears to be most effective of atypical members.> Its main side effects are: Agranulocytosis, Seizures, Hyperthermia> Its side effects profile make it appropriate for treatment of resistant cases.# Olanzapine Is chemically similar to clozapine but of leaves efficacy and causes rapid wt gain.> Risperidone - benzisoxazole: It is 5HT, D2 and a-2 antagonist Its a-2 antagonism contribute to its ability to improve mood and increase motor activity> Chlorpromazine - Its is typical antipsychotic anticholinergic highly sedative> Clozapine appears to be the most effective member of this class and has demonstrated superiority to other atypical agents in preventing suicide;however, its side-effect profile makes it most appropriate for treatment resistant cases Olanzapine is similar neurochemically to clozapine but has a significant risk of inducing weight gain.> Risperidone, a benzisoxazole derivative, is more potent at 5HT2 than D2 receptor sites, like clozapine, but it also exerts significant antagonism, a property that may contribute to its perceived ability to improve mood and increase motor activity.> Risperidone is not as effective as clozapine in treatment resistant cases but does not carry a risk of blood dyscrasias. chlorpromazine and thioridazine, are more sedating and anticholinergic and more likely to cause orthostatic hypotension.
Category:
Psychiatry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now