Which one of the antitubercular drug may precipitate gout :
**Core Concept**
The question tests the student's knowledge of the side effects of antitubercular drugs, specifically those that can precipitate **gout**. This condition is characterized by an excess of **uric acid** in the blood, leading to joint inflammation.
**Why the Correct Answer is Right**
The correct answer is related to the mechanism by which certain antitubercular drugs increase **uric acid** levels. **Pyrazinamide** is known to inhibit the renal excretion of uric acid, thereby increasing its serum levels and potentially precipitating gout.
**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because it does not typically cause an increase in uric acid levels.
**Option B:** Incorrect as it is not commonly associated with gout.
**Option D:** Incorrect because, although it has several side effects, precipitating gout is not a common one.
**Clinical Pearl / High-Yield Fact**
Students should remember that **pyrazinamide** can cause hyperuricemia, leading to gout, due to its effect on uric acid excretion. This is a critical side effect to consider in patients with a history of gout.
**Correct Answer:** D. Pyrazinamide.