Which one is not converted to an active metabolite?
Correct Answer: Lisinopril
Description: Lisinopril: It is the lysine derivative of enalaprilat; does not require hydrolysis to become active ACE inhibitor.
KEY CONCEPT:-
All ACE inhibitors are prodrugs except captopril and lisinopril. Other drugs like enalapril are converted to its active metabolite (enalaprilat) and thus are slow acting.
Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 532
Category:
Pharmacology
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