The side effects of Tacrolimus includes, nephro and hepato toxicity. It can also cause hypeension, tremors, seizure, diabetes mellitus and blurred vision. It should be better avoided with other hepato and renal toxicity drugs. Ref: Manzoor M. Khan (2008), Chapter 4 "Immunesupressive Agents", In the book, "Immunopharmacology", Springer Publications, USA, Page 91 ; Katzung, 9th Edition, Pages 941, 942